PROPOLEOS E HIPERTENSION
| 1: Cardiovasc Toxicol. 2005 Fall;5(4):391-6. |
Role of vagal activity on bradicardic
and hypotensive effects of caffeic
acid phenethyl ester (
Iraz
M, Fadillioglu
E, Tasdemir
S, Erdogan
S.
Department of Pharmacology, Medical Faculty of
Caffeic acid phenethyl ester (
| 2: Biol Pharm Bull. 2005 Oct;28(10):1909-14. |
Antihypertensive
effects of Brazilian propolis: identification of
caffeoylquinic acids as constituents involved in
the hypotension in spontaneously hypertensive rats.
Mishima S, Yoshida
C, Akino S, Sakamoto
T.
Nagaragawa Research Center,
API Co., Ltd; 692-3 Yamasaki, Nagara,
Brazilian propolis was extracted with water or various concentrations of ethanol and
were administered orally to spontaneously hypertensive rats (SHR) and
the effects on blood pressure and heart rate were determined. Single oral
administration of 100 mg/kg of propolis extracts
decreased the blood pressure in SHR. Significant decrease in blood pressure
was observed with propolis extracted with 25 and
70% ethanol. SHR were given orally 5 mg/kg of propolis
extracted with 25 or 70% ethanol, twice a day for 28 d and the effects on
blood pressure and heart rate were compared with control rats. While the blood
pressure in the control group increased day by day, the increase was slower
in rats treated with 25 and 70% ethanol extracts of propolis.
The hypotensive activity of propolis
extracted with 25% ethanol was more significant compared with control group
than with 70% ethanol. Di- and tri-caffeoylquinic acids (CQAs) were
found to be characteristic components of propolis
extracted with 25% ethanol. A single oral administration of 3,4-diCQA,
3,5-diCQA, and 3,4,5-triCQA each at a dose of 10 mg/kg were conducted in SHR.
These three components were found to have antihypertensive effects and therefore
contribute to the antihypertensive effects of propolis
extract. These results suggest that 25% ethanol extract of propolis
is useful for prevention and treatment of hypertension.
| 3: Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S29-30. |
Anti-hypertensive
effects of brazilian propolis
in spontaneously hypertensive rats.
Kubota
Y, Umegaki
K, Kobayashi
K, Tanaka
N, Kagota
S, Nakamura
K, Kunitomo
M, Shinozuka
K.
Department
of Pharmacology,
SUMMARY 1. Changes in the cardiovascular parameters
of Wistar-Kyoto rats (WKY) and spontaneously hypertensive
rats (SHR) were examined following a 4-week diet of either Brazilian propolis
or Eucommia uloides OLIVER
(tochu).
| 4: Fitoterapia. 2002 Nov;73 Suppl 1:S1-6. |
Propolis, an old remedy used in modern
medicine.
Castaldo S, Capasso F.
Department of I.N.P.S. of
Propolis is one of the few natural remedies that
has maintained its popularity over a long period of time. The
pharmacologically active molecules in the propolis
are flavonoids and phenolic
acids and their esters. These components have multiple effects on bacteria,
fungi and viruses. In addition, propolis and its
components have anti-inflammatory and immunomodulatory
activities. Moreover, propolis has been shown to
lower blood pressure and cholesterol levels. However, clinical studies to
substantiate these claims are required.
Publication Types:
· Review
PMID: 12495704 [PubMed - indexed for MEDLINE]
| 5: Arzneimittelforschung. 1978;28(2):291-2. |
Biological properties and clinical application of propolis. X. Preliminary pharmacological
evaluation of ethanol extract of propolis (EEP).
Kleinrok Z, Borzecki Z, Scheller S, Matuga W.
A study consisting of an examination of the acute toxicity of ethanol extract
of propolis (EEP) in mice, its effect on spontaneous
movement in mice and rats, its analgesic properties and its influence on body
temperature in mice was conducted. Also examined was the activity of EEP on
animals under the influence of narcotics and spontaneous movement under the
influence of amphetamine, its effects on blood pressure and respiration in
rats. The results of these examinations indicate that EEP injected i.p. has a weak general effect on the experimental animals.
PMID: 580395 [PubMed
- indexed for MEDLINE]