PROPOLEOS HEPATITIS
| Items 1 - 8 of 8 |
One page. |
| 1: Toxicology. 2004 Mar 1;196(1-2):87-93. |
Antioxidative
natural product protect against econazole-induced liver injuries.
Liu
CF, Lin
CH, Lin
CC, Lin
YH, Chen
CF, Lin
CK, Lin
SC.
The study objective of this research is in order to investigate the hepatoprotective
and therapeutic effects of propolis ethanol extract (PEE) on acute econazole-induced
liver injury. Positive control of various concentrations of PEE on liver function
and the dose-response relationship of liver injury induced by various doses
of econazole were firstly observed from biochemical assay of serum level of
aspartate transaminase (SGOT) and serum alanine transaminase (SGPT) and histopathological
microscopic examination. The hepatoprotective effects of various concentration
of PEE on liver damage induced by hepatotoxic dose (300 mg/kg) of econazole
were observed by the obvious decrement of SGOT and SGPT level and further
confirmed by hepatohistological microscopic examination. The inhibitory effects
of PEE on FeCl(2)-induced (in vitro) or econazole-induced (in vivo) lipid
peroxidation were investigated from the measurement of the formed malonic
dialdehyde (MDA) level in the rat liver homogenate. The IC(50) (microM) of
various concentrations of PEE in the superoxide scavenging activity in econazole
(300 mg/kg)-damaged rat liver homogenate were assessed by cytochrome c reduction
method and compared with that of (+)-alpha-tocopherol. It could be postulated
that the hepatoprotective effect of PEE may be, at least in part, due to their
inhibitory ability on membrane lipid peroxidation and free radical formation
or due to their free radical scavenging ability.
| 2: Phytother Res. 2003 Mar;17(3):250-3. |
The protective effects of Propolis on hepatic injury and its mechanism.
Seo
KW, Park
M, Song
YJ, Kim
SJ, Yoon
KR.
Toxicology Department, National Institute of Toxicological
AbstractPropolis (PP) is a sticky substance that is collected from plants
by honeybees. The purpose of this study was to investigate the protective
effects of PP on hepatotoxicity induced by acetaminophen (AA, paracetamol)
and the mechanism of its hepatoprotective effect. In rat hepatocyte culture,
pretreatment with PP (1, 10, 100, 200 and 400 microg/mL, 24 h) significantly
decreased the cytotoxicity of AA (
PMID: 12672155 [PubMed - indexed for MEDLINE]
| 3: J Ethnopharmacol. 2000 Sep;72(1-2):239-46. |
Cytotoxic, hepatoprotective and free radical scavenging effects
of propolis from
Banskota AH,
Tezuka Y, Adnyana IK, Midorikawa K,
Matsushige K,
Message D, Huertas AA, Kadota S.
Department of Natural Products
Chemistry,
Propolis is a resinous hive product collected by honeybees from various plant
sources. The composition of the propolis depends upon the time, vegetation
and the area of collection. Thus, quality evaluation of the propolis is important,
before use in food and beverages. For this propose three different biological
activities were carried out, i.e. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free
radical scavenging activity, cytotoxicity and hepatoprotective activity, of
MeOH and water extracts of nine different propolis from Brazil, Peru, the
Netherlands and China. The results showed that water extracts of six Brazilian
and a Chinese propolis possessed stronger DPPH free radical scavenging activity
than the corresponding MeOH extract, whereas in the case of Netherlands and
Peruvian propolis MeOH extract exhibited stronger DPPH free radical scavenging
activity. The MeOH extracts of all propolis possessed stronger cytotoxicity
than the corresponding water extract towards murine colon 26-L5 carcinoma
and human HT-1080 fibrosarcoma cells. The result of hepatoprotective activity
of Brazilian propolis on D-galactosamine (D-GalN)/tumor necrosis factor-alpha
(TNF-alpha)-induced cell death in primary cultured mouse hepatocytes were
found in accordance with the grade set up by beekeepers in Brazil.
| 4: Biol Pharm Bull. 1999 Nov;22(11):1237-9. |
Effect of propolis extract on D-galactosamine-induced hepatic injury
in rats.
Sugimoto Y, Tarumi T, Kaneko Y, Isayama S, Kawai N, Sugimoto H, Yamada H, Kamei C.
Department of Pharmacology, Faculty
of Pharmaceutical Sciences,
The preventive effect of propolis extract on D-galactosamine-induced hepatic
injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine
aminotransferase (ALT) activities were significantly increased at 24 h after
intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis
extract was administered orally three times in doses of 3 or 30 mg/kg at 18
h and 1 h before and 8 h after D-galactosamine injection. The extract itself
and the vehicle alone (dextran) caused no significant changes in serum AST
or ALT activities. Treatment with the extract dose-dependently prevented the
increases in serum AST and ALT activities induced by D-galactosamine, and
significant inhibition was observed at a dose of 30 mg/kg. These results suggested
that propolis extract may have an ameliorating effect on hepatic dysfunction.
| 5: Pharmacol Res. 1997 Jan;35(1):1-4. |
Effects of Cuban red propolis on galactosamine-induced hepatitis
in rats.
Rodriguez S,
Ancheta O, Ramos ME, Remirez D, Rojas E, Gonzalez R.
Electron Microscopy Laboratory,
Using transmission electron microscopy and biochemical analysis, the effect
of cuban red propolis against hepatitis induced by 1,000 mg kg-1 of galactosamine
in rats was studied. An ethanolic extract of propolis was prepared and it
was given to rats at doses of 10, 50 and 100 mg kg-1, 30 min before the hepatotoxin.
Propolis extract prevented hepatocytes alterations induced by galactosamine.
It was mainly seen in rough endoplasmic reticulum, Golgi complex, nucleus
and plasma membrane of hepatocytes. Propolis extract induced reversion of
the increased activity of alanine aminotransferase and malondialdehyde concentration
in the serum of rats treated with galactosamine. The probable role of antioxidant
activity of propolis in the prevention of hepatitis is discussed in this paper.
| 6: Arch Med Res. 1996 Autumn;27(3):285-9. |
Histopathological evaluation on the effect of red propolis on liver
damage induced by CCl4 in rats.
Merino N, Gonzalez R, Gonzalez A, Remirez D.
Departamento de Farmacologia y Toxicologia, Centro Nacional de Investigaciones
Cientificas, Havana, Cuba.
A histopathological evaluation
was performed on liver of rats treated with carbon tetrachloride (CCl4) and
25,50 and 100 mg/kg of Cuban red propolis (RP) extract. Additionally, alanine
aminotransferase (ALT) in serum and liver triglycerides were determined in
all animals. The morphometric study included the count of ballooned cells
at the zone III of the Rappaport acini and the assessment of a software program
to estimate the extension of steatosis area. A significant reduction of ballooned
cells count in liver was observed at three dose levels of RP extract with
respect to rats treated only with CCl4. Also, a certain reduction of steatosis
degree as well as decreased concentration of liver triglycerides and ALT activity
were found in three groups of rats treated with RP extract and CCl4 in relation
to those treated with the hepatotoxin. Taken together, the histopathological
and biochemical findings show hepatoprotective effects of RP extract in CCl4-induced
liver damage in rats, probably due to the antioxidant effect of RP.
PMID: 8854383 [PubMed - indexed for MEDLINE]
| 7: Eksp Klin Farmakol. 1994 Jul-Aug;57(4):39-42. |
[The liver-protective
properties of the pediatric drug form of propolis in animals of different
age groups]
[Article in Russian]
Drogovoz
SM, Tikhonov
AI, Slyshkov
VV, Sal'nikova
SI.
The pharmacological activity of a pediatric formulation of the phenolic hydrophobic
drug propolis was studied in the experiments on albino rats of various age
with toxic liver damages of various duration and in acute hepatic ischemia.
In all models of hepatic abnormalities, the drug was found to show antioxidative
properties which were moderate (30-60%). In addition, there were improvements
in hepatic secretion of bile, cholic acids, and cholesterol. On the other
hand, the membrane-stabilizing effect of the drug was exerted in not all the
tested models of hepatic damage.
PMID: 7950783 [PubMed - indexed for MEDLINE]
| 8: Virologie. 1980 Oct-Dec;31(4):273-8. |
Investigations concerning the action of serveral chemical and biological
agents on HBsAg.
Morfei A, Burducea O, Neuman R, Cajal N, Copelovici Y,
Crisan I.
Native and purified HBsAg preparations
were subjected in vitro to the action of cetylpyridinium bromide (Bromocet),
hibitan-chlorhexidine (Hibiscrub), chloramine B and propolis extract, at different
concentrations and for various time intervals. The effect of these agents
on the serological reactivity of HBsAg was tested by electroimmunodiffusion
(EID) and radioimmunoassay (RIA). Chloramine B and the propolis extract had
a significant inhibitory effect-ascertained by both EID and RIA - on purified
HBsAg, but not on the native preparation. The inhibition exerted by Bromocet
and Hibiscrub indicated by EID results was not confirmed by RIA.
PMID: 7257176 [PubMed - indexed for MEDLINE]