PROPOLEOS ANTINFLAMATORIO
| Items 1 - 18 of 18 |
One page. |
| 1: Int Immunopharmacol. 2005 Feb;5(2):359-68. |
Effects of
Brazilian and Bulgarian propolis on bactericidal activity of macrophages against
Salmonella Typhimurium.
Orsi
RO, Sforcin
JM, Funari
SR, Bankova
V.
Department of Production and Animal Exploration-School of Veterinary Medicine
and Animal Husbandry-UNESP, 18618-000 Botucatu, SP,
Propolis has been used in folk medicine since ancient times due to its many
biological properties, such as antimicrobial, antiinflammatory, antioxidant,
immunomodulatory activities, among others. Macrophages play an important role
in the early phase of Salmonella infection. In this work, macrophages were
prestimulated with Brazilian or Bulgarian propolis and subsequently challenged
with Salmonella Typhimurium at different macrophage/bacteria ratio. After
60 min of incubation, cells were harvested with Triton-X to lyse the macrophages.
To assess the bactericidal activity, the number of colony-forming units (CFU)
of S. typhimurium was determined by plating 0.1 mL in Mueller Hinton agar.
After 24 h, CFU were counted, and the percentage of bactericidal activity
was obtained. Propolis from
PMID: 15652765 [PubMed - indexed for MEDLINE]
| 2: Biol Pharm Bull. 2003 Apr;26(4):487-91. |
Caffeic acid
phenethyl ester (CAPE) analogues: potent nitric oxide inhibitors from the
Nagaoka T, Banskota AH,
Tezuka Y, Midorikawa K,
Matsushige K,
Kadota S.
The MeOH and water extracts of the
| 3: Fitoterapia. 2002 Nov;73 Suppl 1:S21-9. |
Antioxidant
activity of propolis: role of caffeic acid phenethyl ester and galangin.
Russo
A, Longo
R, Vanella
A.
Department of Biochemistry, Medical Chemistry and Molecular Biology, University
of Catania, V.le A. Doria 6, 95125, Catania, Italy. alrusso@mbow.unict.it
Propolis, a natural product produced by the honeybee, has been used for thousands
of years in folk medicine for several purposes. The extract contains amino
acids, phenolic acids, phenolic acid esters, flavonoids, cinnamic acid, terpenes
and caffeic acid. It possesses several biological activities such as antiinflammatory,
immunostimulatory, antiviral and antibacterial. The exact mode of physiological
or biochemical mechanisms responsible for the medical effects, however, is
yet to be determined. In this work, we have investigated the antioxidant activity
of a propolis extract deprived of caffeic acid phenethyl ester (
| 4: Curr Eye Res. 2001 Oct;23(4):291-7. |
Effect of caffeic
acid phenethyl ester on corneal neovascularization in rats.
Totan Y, Aydin E, Cekic O, Cihan Dagloglu M,
Borazan M, Daglioglu K,
Gultek A.
Department of Ophthalmology,
PURPOSE: Caffeic acid phenethyl ester (
| 5: Phytother Res. 2001 Nov;15(7):561-71. |
Recent progress
in pharmacological research of propolis.
Banskota
AH, Tezuka
Y, Kadota
S.
Department of Natural Products Chemistry,
Propolis is a resinous hive product collected by honeybees from various plant
sources. It is a popular folk medicine possessing a broad spectrum of biological
activities. It has also been used as a health drink in various Asian, European
and American countries. Several groups of researchers have focused their attention
on the biological activity of propolis and its active principles. Many scientific
articles are published every year in different international journals related
to the pharmacological properties of propolis. This review article compiles
recent findings (since 1995) on the pharmacological properties of propolis
focusing on its antihepatotoxic, antitumour, antioxidative, antimicrobial
and antiinflammatory properties. The possible mechanism of action of propolis
as well as the active compounds are discussed.
Publication Types:
· Review
PMID: 11746834 [PubMed - indexed for MEDLINE]
| 6: Arzneimittelforschung. 2000 Apr;50(4):373-9. |
Antiapoptotic effects
of propolis extract and propol on human macrophages exposed to minimally modified
low density lipoprotein.
Claus
R, Kinscherf
R, Gehrke
C, Bonaterra
G, Basnet
P, Metz
J, Deigner
HP.
An aqueous extract of propolis and the phenolic component of propolis, propol,
were assayed for antioxidative and antiapoptotic properties. Both additions
inhibited Cu(2+)-initiated low density lipoprotein (LDL) oxidation as characterized
by a reduction of the lag time, reduced the increase of relative electrophoretic
mobility during oxidation and markedly diminished apoptosis of human macrophages
exposed to minimally modified (mmLDL). Moreover, aqueous propolis extract
and propol blocked the mmLDL-induced decrease of glutathione (GSH) and the
activation of the transcription factor NF-kappa B in these cells. The potent
phenolic antioxidant propol thus expands the capability of cells to neutralize
oxidative stress and to prevent apoptosis and is therefore suggested to significantly
contribute to the antiinflammatory and antioxidative effects of propolis.
| 7: Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9090-5. |
Caffeic acid
phenethyl ester is a potent and specific inhibitor of activation of nuclear
transcription factor NF-kappa B.
Natarajan
K, Singh
S, Burke
TR Jr, Grunberger
D, Aggarwal
BB.
Department of Molecular Oncology, University of
Caffeic acid phenethyl ester (
| 8: Orv Hetil. 1996 Jun 23;137(25):1365-70. |
Comment in:
· Orv Hetil. 1996 Jun 23;137(25):1363-4.
[Local treatment
of rheumatic diseases with propolis compounds]
[Article in Hungarian]
Siro
B, Szelekovszky
S, Lakatos
B, Mady
G, Szathmari
E, Karanyi
Z.
Debreceni Orvostudomanyi Egyetem I. Belgyogyaszati Klinika.
The authors conducted a single blind, placebo controlled local therapy trial
on a total of 190 patients involving the use of materials (i) topically and
(ii) by iontophoresis for pain and/or inflammation of the organs of movement.
The materials used comprised of the following: (i) purified propolis and propolis
saturated with antiinflammatory trace metal elements and (ii) propolis saturated
with trace metal elements and poplar bud ointment saturated with trace metal
elements also. Both methods of application using all the three preparations
significantly improved symptoms. The preparations saturated with metallic
ions were more effective. The mild effect of the placebo treatment is explained
by the treatment procedure itself. Side effects
were not observed.
Publication Types:
PMID: 8757085 [PubMed - indexed for MEDLINE]
| 9: Drugs Exp Clin Res. 1995;21(6):229-36. |
The use of aqueous
propolis extract against radiation-induced damage.
El-Ghazaly
MA, Khayyal
MT.
Department of Drug Radiation Research, National Centre for Radiation Research
and Technology,
Whole body exposure to gamma radiation has been experimentally shown to exaggerate
inflammatory responses and to enhance the release of mediators. A thirteen
per cent aqueous extract of propolis (bee glue) was previously shown to have
potent antiinflammatory activity. The present study was carried out to show
whether the extract could influence the exaggerated inflammatory response
in irradiated animals. Rats were exposed to acute (2 and 6 Gy) & fractionated
(1 Gy/week) doses of gamma ionizing radiation. Treatment with the aqueous
extract orally (5 ml/kg) before and after radiation exposure markedly reduced
the exaggerated paw oedema response to carrageenan. In the acute phase of
adjuvant-induced arthritis, exposure to ionizing radiation caused an increase
in serum acid phosphatase level. Malondialdehyde concentration in plasma and
superoxide dismutase activity in blood significantly increased. Treatment
with aqueous propolis extract prior to irradiation reduced malondialdehyde
concentration in plasma and normalized the serum acid phosphatase level. The
extract stimulated the release of superoxide dismutase enzyme. Aqueous propolis
extract could possibly be of therapeutic value in protecting against inflammatory
responses induced by gamma radiation.
| 10: Z Naturforsch [C]. 1994 Jan-Feb;49(1-2):39-43. |
Biochemical activities
of propolis-extracts. III. Inhibition of dihydrofolate reductase.
Strehl
E, Volpert
R, Elstner
EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische Universitat
Munchen.
Ethanolic and aqueous extracts of the natural compound PROPOLIS indicate substantial
antiinflammatory functions as well as antibiotic activities in vitro and in
vivo. The exact mode of physiological or biochemical mechanisms responsible
for the medical effects, however, is all but clear. The standardization on
the basis of quantitative determination of prominent components of these extracts
have been substituted recently by simple biochemical model reactions including
photodynamic properties. In this communication we report on the inhibitory
activity of an aqueous extract of propolis on the enzyme dihydrofolate reductase.
This activity may at least partially be due to the content of caffeic acid,
as revealed by HPLC chromatography and comparative activity tests of representative
ingredients of the propolis extract. This result may explain some of the protective
functions of propolis, similar to those shown for several "non-steroidal
antiinflammatory drugs", NSAIDs.
PMID: 8148008 [PubMed - indexed for MEDLINE]
| 11: Z Naturforsch [C]. 1993 Nov-Dec;48(11-12):858-62. |
Biochemical activities
of propolis extracts. II. Photodynamic activities.
Volpert
R, Elstner
EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische Universitat
Munchen, Bundesrepublik Deutschland.
Ethanolic and aqueous extracts of the "bee glue" Propolis exhibit
antioxidative properties and are used as antiinflammatory drugs in folk medicine.
In order to standardize the principle activities of prominent components of
these extracts, simple biochemical tests have been introduced in the preceding
paper. These activity tests prove the high antioxidative and inhibitory capacities
of aqueous and ethanolic extracts of propolis in vitro. In the present communication
we report on experiments documenting photodynamic quenching properties of
these extracts. Using riboflavin, rose bengal or hematoporphyrin as photoactivators
and ketomethylthiobutyric acid or crocin as indicators, the protective functions
of propolis preparations can be demonstrated. The results indicate that the
aqueous extracts are more active than the corresponding ethanolic preparation.
PMID: 8297423 [PubMed - indexed for MEDLINE]
| 12: Z Naturforsch [C]. 1993 Nov-Dec;48(11-12):851-7. |
Biochemical activities
of propolis extracts. I. Standardization and antioxidative properties of ethanolic
and aqueous derivatives.
Volpert
R, Elstner
EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische Universitat
Munchen, Bundesrepublik Deutschland.
Ethanolic extracts of Propolis are used as antiinflammatory and wound healing
drugs since ancient times. In order to facilitate a comparison of different
extracts, the standardization on the basis of quantitative determination of
prominent components of these extracts has been substituted for simple biochemical
"activity" tests. One of these activity tests bases on the inhibition
of peroxidase-catalyzed oxidation of indole acetic acid indicating the presence
of a defined mixture of monophenolic and diphenolic compounds. Other tests
(diaphorase-catalyzed reductions and xanthine oxidase-catalyzed oxidations)
demonstrate significant radical scavenging properties. Water-soluble extracts
of propolis exhibit higher antioxidative and inhibitory activities as compared
to the ethanolic extract.
PMID: 8297422 [PubMed - indexed for MEDLINE]
| 13: Cancer Res. 1993 Mar 15;53(6):1255-61. |
Inhibition of tumor
promoter-mediated processes in mouse skin and bovine lens by caffeic acid
phenethyl ester.
Frenkel K, Wei H, Bhimani R, Ye J, Zadunaisky JA,
Huang MT, Ferraro T, Conney AH, Grunberger D.
Department of Environmental Medicine,
New York University Medical Center, New York 10016-6451.
Caffeic acid phenethyl ester (CAPE) was isolated from propolis (a product
of honeybee hives) that has been used in folk medicine as a potent antiinflammatory
agent. CAPE is cytotoxic to tumor and virally transformed but not to normal
cells. Our main goal was to establish whether CAPE inhibits the tumor promoter
(12-O-tetradecanoylphorbol-13-acetate)-induced processes associated with carcinogenesis.
Topical treatment of SENCAR mice with very low doses (0.1-6.5 nmol/topical
treatment) of CAPE strongly inhibits the following 12-O-tetradecanoylphorbol-13-acetate-mediated
oxidative processes that are considered essential for tumor promotion: (a)
polymorphonuclear leukocyte infiltration into mouse skin and ears, as quantified
by myeloperoxidase activity; (b) hydrogen peroxide (H2O2) production; and
(c) formation of oxidized bases in epidermal DNA, as measured by 5-hydroxymethyluracil
and 8-hydroxylguanine. A 0.5-nmol dose of CAPE suppresses the oxidative burst
of human polymorphonuclear leukocytes by 50%. At higher doses (1-10 mumol),
CAPE inhibits edema and ornithine decarboxylase induction in CD-1 and SENCAR
mice. Interestingly, we discovered that 12-O-tetradecanoylphorbol-13-acetate-induced
H2O2 production in bovine lenses also is inhibited by CAPE. Cumulatively,
these findings point to CAPE as being a potent chemopreventive agent, which
may be useful in combating diseases with strong inflammatory and/or oxidative
stress components, i.e., various types of cancer and possibly cataract development.
PMID: 7680281 [PubMed - indexed for MEDLINE]
| 14: Drugs Exp Clin Res. 1993;19(5):197-203. |
Mechanisms involved
in the antiinflammatory effect of propolis extract.
Khayyal
MT, el-Ghazaly
MA, el-Khatib
AS.
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt.
Propolis is a natural product produced by the honey bee. The extract contains
amino acids, flavanoids, terpenes and cinnamic acid derivatives. In various
in vitro models propolis extract was shown to inhibit platelet aggregation
and to inhibit eicosanoid synthesis, suggesting that it might have potent
antiinflammatory properties. A 13% aqueous extract was tested orally in three
dose levels (1, 5 and 10 ml/kg) on the carrageenan rat paw oedema model and
on adjuvant-induced arthritis in rats. In both models, the extract showed
potent dose-related antiinflammatory activity, which compared well with that
of diclofenac (as a reference standard). The extract was then tested on an
isolated sensitized guinea pig lung preparation to study its effect on the
release of prostaglandins, leukotrienes and histamine. It is concluded that
propolis extract has potent antiinflammatory properties in vivo. Its activity
can be well correlated with its effects on the release of various mediators
of inflammation.
PMID: 7513636 [PubMed - indexed for MEDLINE]
| 15: J Ethnopharmacol. 1991 Oct;35(1):77-82. |
Antibacterial, antifungal,
antiamoebic, antiinflammatory and antipyretic studies on propolis bee products.
Dobrowolski JW,
Vohora SB, Sharma K, Shah SA, Naqvi SA, Dandiya PC.
Institute of Management and Protection
of Environment, Krakow, Poland.
PMID: 1753797 [PubMed - indexed for MEDLINE]
| 16: Rev Chir Oncol Radiol O R L Oftalmol Stomatol Ser Stomatol. 1989 Apr-Jun;36(2):91-8. |
[Apiphytotherapeutic
original preparations in the treatment of chronic marginal parodontopathies.
A clinical and microbiological study]
[Article in Romanian]
Gafar
M, Dumitriu
H, Dumitriu
S, Guti
L.
The paper presents results obtained by the treatment of chronic marginal parodontopathies
with natural products of apiarian derivatives and vegetal extracts. These
are original preparations such as Proparodont, sage extracts, watercress extracts,
etc., by comparison with other similar existing products, and with zinc chloride.
The clinical study evaluated the "inflammation status of the marginal
prodontium" on the basis of variations in the PMA index. The microbiological
study has established the bacteriostatic and the bactericidal activities of
the products employed. The results obtained stress the high antimicrobial
activity of the original products called Proparodont, and stress its antimycotic
effects, especially against Candida albicans. The blackwort (Symphytum off.)
extracts have a good repair effect, especially after surgical procedures.
The complex original products based on propolis and vegetal extracts are indicated
in the treatment of inflammatory lesions of the gingivo-parodontal tissues,
and of the buccal mucosa. They also have antimicrobial effects, as well as
antimycotic, antiinflammatory and antiscar effects. They de not have side
effects which are characteristic for other medicinal drugs employed in the
treatment of chronic marginal parodontopathies.
PMID: 2535077 [PubMed - indexed for MEDLINE]
| 17: Vestn Khir Im I I Grek. 1985 May;134(5):119-22. |
[Use of propolis
in the treatment of local suppurative infection]
[Article in Russian]
Tsarev
NI, Petrik
EV, Aleksandrova
VI.
Experience with the treatment of 460 patients with panaritium, abscesses,
phlegmons, infectious wounds have shown that propolis is an expedient remedy
(in additional to the the routine treatment). They have shown the stimulating,
antiinflammatory and anti-microbial action of propolis.
PMID: 4035908 [PubMed - indexed for MEDLINE]
| 18: Agents Actions Suppl. 1982;10:129-34. |
Influence of flavonoids
on capillary permeability, carrageenin edema and histamine and PGE2 spasms.
Metzner
J, Bekemeier
H, Weber
FG.
Bioflavonoids from propolis and 6-halogenated flavanones were tested with
respect to their effects on increased capillary permeability and to their
antiinflammatory and antispasmodic actions, respectively. The 5,7,8-trimethoxy-
and 6-fluorflavanone seem to be the best compounds tested.
PMID: 6956213 [PubMed - indexed for MEDLINE]